(CS-024) Utilization of Piscine Acellular Dermal Matrix for Coverage Over Tendon and Bone in Diabetics: A Case Series

When treating chronic diabetic ulcerations, the wound care provider often turns to advanced allogenic or xenogenic skin graft substitutes for soft tissue coverage. The utilization of xenografts derived from piscine acellular dermal matrix (ADM) has emerged as a promising approach for coverage over tendon and bone defects. Piscine grafts have gained rapid recognition in wound care for their native dermal structural, porosity and biomechanical properties that favors rapid cell ingrowth and provides a natural bacterial barrier rich in Omega3 fatty acids. This case series aimed to evaluate the efficacy and clinical outcomes associated with the utilization of piscine ADM in a series of patients with tendon and bone defects.

Methods:

A retrospective analysis was conducted on a series of patients who underwent surgical grafting using piscine ADM for coverage over tendon and bone defects. Data regarding patient demographics, defect characteristics, surgical technique, postoperative outcomes, and complications were collected and analyzed.

Results:

The piscine ADM was successfully integrated and provided adequate coverage in all cases, resulting in improved wound healing, reduced infection rates, and enhanced functional recovery. No cases of graft rejection or significant complications were reported during the follow-up period.

Discussion:

This case series demonstrates the successful utilization of piscine ADM for coverage over tendon and bone defects, offering a promising treatment option for limb salvage. The particulate form of fish skin graft appears to be an excellent treatment option for uneven wounds despite their challenging nature, perhaps owing to the combination of proteins and fatty acids present in the minimally processed graft. Piscine ADM xenografts exhibit biocompatibility and favorable clinical outcomes, making them a viable option for surgical applications. Further prospective studies with larger sample sizes are warranted to validate these findings and assess the long-term outcomes and durability of piscine ADM xenografts.

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