(CS-046) Tissue regeneration by decellularized matrix from fish skin: usage algorithm for optimizing results. The Italian experience.

Tissue regeneration through dermal matrix decellularized from fish skin has now entered the routine treatment of skin lesions. The excellent results in terms of functionality and aesthetics, combined with the extreme versatility of the product, make it a "trump card" when treating even "difficult" skin lesions. However, proper preparation of the lesion bed and careful periodic monitoring are needed to ensure the best results. From our experience, we have drawn up a treatment algorithm that is easy to apply, guaranteeing an excellent chance of optimal results.

Methods:

100 patients (a total of 110 injuries, acute and chronic, of various etiologies) were treated with decellularized fish skin.

The therapeutic course followed a precise pathway, from the intake of the chosen lesion, to the preparation of the lesion bed according to the principles of Wound Bed Preparation, to the grafting of the biomaterial. Patients were then reassessed weekly, with secondary dressing changes, until complete healing (which occurred in more than 90% of cases).  Primary and secondary dressing selection criteria are provided for each step, as well as any indication for combination with other technologies (e.g., NPWT).

Results:

As indicated, complete healing was achieved in more than 90% of cases, rapidly, with excellent clinical, aesthetic and functional results, resulting in regeneration of tissue with characteristics entirely similar to those of the native.
The indicated treatment algorithm made it possible to follow a pre-established, simple and linear pathway, reproducible in any Wound Care Center, being based on clinical choices that take into account the material in use and the phase of the treatment itself

Discussion:

Although tissue biostimulation with decellularized fish skin is a simple technique to perform, a precise treatment scheme must be followed, which guarantees the best clinical results, right from the selection of the lesion, up to its complete follow-up. From the Italian experience we have performed an algorithm that we consider optimal for the best rational use of this biostimulant.

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