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Case Series/Study

(CS-081) Successful Treatment of Calciphylaxis Ulcers with Novel Ovine Forestomach Matrix Composite with Hyaluronic Acid: A Case Series

Introduction: Calciphylaxis is a serious, uncommon disease in which calcium accumulates in small blood vessels of the fat and skin tissues frequently resulting in painful, non-healing skin ulcerations (Kodumudi et al. 2020). Ovine forestomach matrix (OFM) has been utilized in severe, chronic and, challenging ulcerations for many years (Bosque et al. 2021; Chaffin et al. 2021). This case series highlights one provider's use of a novel OFM composite with hyaluronic acid (OFM-HA*) to treat calciphylaxis ulcerations. 

Methods: This is an observational, retrospective case series evaluating efficacy of OFM-HA in the management of multiple calciphylaxis skin ulcerations. This case series is a follow up of a single case report pilot study previously presented. 

Results: All lesions showed significant clinical improvement with two chronic calciphylaxis ulcerations healing.  

Discussion:

Ulcerations due to calciphylaxis are challenging to diagnose and treat due to rarity and significant systemic complexity. Novel OFM-HA composite demonstrated a clinically safe and effective option to treat calciphylaxis ulcerations with favorable handling characteristics. A larger case series and/or prospective study may be conducted to further elucidate the potential for the treatment of challenging atypical wounds such as calciphylaxis.


Trademarked Items: *OFM-HA: Symphony (Aroa Biosurgery LTD, Auckland, NZ)

References: Bosque, B. A., C. Frampton, A. E. Chaffin, G. A. Bohn, K. Woo, C. DeLeonardis, B. D. Lepow, M. M. Melin, T. Madu, S. G. Dowling, and B. C. H. May. 2021. 'Retrospective real-world comparative effectiveness of ovine forestomach matrix and collagen/ORC in the treatment of diabetic foot ulcers', Int Wound J, 2021 Aug 6: 741-53.

Chaffin, A. E., S. G. Dowling, M. S. Kosyk, and B. A. Bosque. 2021. 'Surgical reconstruction of pilonidal sinus disease with concomitant extracellular matrix graft placement: a case series', J Wound Care, 30: S28-S34.

Kodumudi, V., G. M. Jeha, N. Mydlo, and A. D. Kaye. 2020. 'Management of Cutaneous Calciphylaxis', Adv Ther, 37: 4797-807.