(PI-021) Measurement of Tissue Oxygenation and Temperature in Chronic Wounds Treated with Cyclical Pressurized Topical Oxygen Therapy

Introduction: The objective of this research was to assess healing of wounds treated with Cyclical pressurized topical oxygen therapy (CPTOT)* using a novel multispectral near-infrared spectroscopy (NIRS) imaging device. Topical oxygen therapy has been shown to increase tissue oxygenation and sustain it over time, resulting in reduced infection, improved angiogenesis, and the formation of higher tensile strength collagen during wound healing. ^1–3Cyclical pressurized topical oxygen therapy (CPTOT) combines high concentration oxygen delivery with therapeutic level cyclical compression, which reduces edema, improves wound bed perfusion, and allows more efficient oxygen diffusion, nutrient exchange, and removal of inflammatory factors.

Methods: This retrospective case series included subjects with chronic ulcers who underwent treatment with CPTOT and evaluation with multispectral NIRS. A point-of-care multispectral NIRS imaging device** was used to measure tissue oxygenation (StO2) and temperature. CPTOT was self-administered by the patients in their own homes.

Results:

NIRS data provided objective measures of increases in StO2, allowing for quantitative assessment of oxygen delivery to the tissue.

Discussion: NIRS is a useful tool for quantifying tissue oxygenation. CPTOT effectively increases tissue oxygenation in chronic wounds.

Trademarked Items: *TWO2, AOTI, Inc., Oceanside, CA
**MIMOSA Pro; MIMOSA Diagnostics, Inc., Toronto, ON

References: 1. Gordillo GM, Sen CK. Evidence-Based Recommendations for the Use of Topical Oxygen Therapy in the Treatment of Lower Extremity Wounds. Int J Low Extrem Wounds. 2009;8(2):105-111. doi:10.1177/1534734609335149
2. Gordillo GM, Roy S, Khanna S, et al. Topical oxygen therapy induces vascular endothelial growth factor expression and improves closure of clinically presented chronic wounds. Clin Exp Pharmacol Physiol. 2008;35(8):957-964. doi:10.1111/j.1440-1681.2008.04934.x
3. Fries RB, Wallace WA, Roy S, et al. Dermal excisional wound healing in pigs following treatment with topically applied pure oxygen. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 2005;579(1-2):172-181. doi:10.1016/J.MRFMMM.2005.02.023