(EBP-007) Retrospective Study of Amniotic Membrane Use on Non-Healing Venous Stasis Ulcers and Diabetic Foot Ulcers

Shenlone Wu, DO – University of Nevada- Las Vegas

Introduction: This is a retrospective chart review comparing wound size changes using the only standard of care (SOC) versus SOC with an amniotic membrane (AM) in patients with non-healing venous stasis leg ulcers (VLU) and diabetic foot ulcers (DFU).

Methods: Subjects in the study are chosen when their wound failed to improve significantly after 5 weeks using SOC alone, and thus, the application of AM was used as an additional treatment for 5 additional weeks. There were 21 patients identified. Patients’ ages range from 44 to 86. 9 ulcers were DFU, and 12 ulcers were VLU.

Results: In the VLU group, patients’ wound area decreased 1.92% on average with SOC alone, and their wound areas decreased 57.25% on average after SOC with AM. Overall, SOC alone resulted in an average 5% increase in wound area, whereas SOC with AM resulted in an average 50.81% reduction in wound area. Wound size reduction using SOC with AM versus SOC alone is statistically significant (p=0.0001). Comparison between size reduction using SOC with AM in DFU versus VLU patients is statistically insignificant (p=0.17), which means that SOC with AM is equally effective in both DFU and VLU patients

Discussion:

We purposely selected challenging wounds to evaluate the efficacy of AM treatment. Both DFU and VLU patients were all refractory to SOC treatment after 5 weeks. In fact, VLU patients overall have wound size larger than the initial SOC treatment. DFU patients on average have minimal improvement with SOC treatment. Compared to the 5 weeks of SOC treatment with AM, the change in wound size is significant. We concluded that amniotic membrane application with standard of care is more efficacious in non-healing VLU and DFU.

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