(CS-074) New Amniotic Allograft* Used to Treat Clinically Challenging Chronic Wounds
Introduction: This case series is comprised of clinically challenging chronic wounds in patients with multiple comorbidities such as congestive heart failure, arterial insufficiency, hypertension, neuropathy, lymphedema, paraplegia, and nicotine dependence.
Methods: We selected 4 complex patients with chronic wounds to evaluate the Cygnus Matrix amniotic allograft and Cygnus Max umbilical cord membrane in wound closure. We treated a 68-year old male with BKA pressure wound, a 60 year-old male with a venous leg ulcer, a 75 year-old female with an arterial insufficiency wound, and a 68 year-old male with a pressure ulcer.
Results: All wounds responded with a progress to wound closure after treatment with traditional debridement and Cygnus matrix and Cygnus max applications. The 2-year chronic pressure ulcer wound improved from 2.28W x 1.82L x 0.3D cm (total 1.24 cm3) to closure
• The 1-year BKA pressure wound improved from 2.75L x 2.15W x 1.0D cm (total 5.91 cm3) to 1.0L x 1.1W x 0.2D cm (total 0.22 cm3)
• The 2-year arterial insufficiency wound improved from 18.1L x 7.5W x 0.3D cm (total 40.72 cm3) to 12.78L x 5.64W x 0.1D cm (total 7.2 cm3)
before the patient was lost to COVID-19 death.
• The 10-year chronic venous leg ulcer maintained sized from 6.36L x 3.67W x 0.2D cm (total 4.66 cm3 ) to5.83L x 3.66W x 0.2D cm (total 4.22 cm3) before
the patient was lost to positive COVID-19 diagnosis and positive Rocky Mountain Spotted Fever diagnosis.
Discussion: This case series of clinically challenging chronic wounds in patients with multiple comorbidities such as congestive heart failure, arterial insufficiency, hypertension, neuropathy, lymphedema, paraplegia, and nicotine dependence, demonstrates a notable rate of wound closure after advanced care treatment of CYGNUS Matrix and CYGNUS Max applications.
We believe the never delaminated and intact intermediate/spongy layer of the CYGNUS Matrix may contribute to the increased rate of wound closure.