(CS-047) Limb Preservation and Functional Restoration Using Three-Dimensional Perfusion Decellularized Porcine Hepatic Wound Matrix

Raymond Abdo, DPM, CWS – St. Louis Foot and Ankle, LLC

Introduction:

Lower extremity wounds in patients with multiple comorbidities require urgent treatment to prevent limb loss with the primary goal to reach wound closure and preserve limb function. This abstract demonstrates the use of Miro3D® Wound Matrix (Reprise Biomedical, Inc., Minneapolis, MN), a porcine-derived acellular collagen matrix with a unique three-dimensional shape including a 2cm thickness, as a beneficial solution for deep, tunneling, and irregular wound beds.

Methods:

A retrospective case series was conducted on a small group of patients with complex, challenging-to-heal lower extremity wounds treated with a three-dimensional perfusion decellularized porcine hepatic wound matrix. Data collected included demographics, comorbid conditions, previous treatments, and wound characteristics including length, width, and depth. Healing rates, number of product applications, additional surgical treatments used, and adverse events were also reviewed. The protocol encompassed pre- and post-operative care, as well as comprehensive treatment throughout the continuum of care to assess wound healing rates and closure.

Results:

All patients had complex deep or tunneling wounds in the foot or ankle, with the added complication of comorbidities. All patients healed these deep or tunneling wounds without requiring amputation, other wound coverings, or split thickness grafts for final closure. Postoperatively, integration of Miro3D resulted in a significant reduction in wound depth and functional limbs were maintained to enhance mobility and improve patient quality of life.

Discussion:

The three-dimensional perfusion decellularized porcine hepatic wound matrix, sold under the tradename Miro3D, is an innovative technology that stands apart from other acellular collagen matrices available for deep, tunneling, and irregular wounds. The matrix’s unique porous structure enables conformity and rapid integration into the wound bed. The application of Miro3D, followed by standard wound care, was shown to be effective for complex, challenging-to-heal lower extremity wound treatment. Achieving functional outcomes using Miro3D enhances patient quality of life.

Trademarked Items: Miro3D

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